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ACP Journal Club |15 November 2016

Review: In adults with diabetes, aspirin does not prevent CV events compared with placebo

Harvey J. Murff, MD, MPH

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Kunutsor SK, Seidu S, Khunti K. Aspirin for primary prevention of cardiovascular and all-cause mortality events in diabetes: updated meta-analysis of randomized controlled trials. Diabet Med. 2016. [Epub ahead of print]. 27086572

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Cardiology:

Endocrinology:

In patients with diabetes, what are the efficacy and safety of aspirin for primary prevention of cardiovascular (CV) events and mortality?
Included studies compared aspirin with placebo or no treatment for ≥ 12 months in adults ≥ 18 years of age who had diabetes mellitus and no history or clinical evidence of CV disease (CVD). Exclusion criteria included comparisons of aspirin with other antiplatelet agents or studies involving patients with known CVD. Outcomes included major adverse CV events (MACE) (composite of nonfatal myocardial infarction [MI], nonfatal stroke, or CV mortality), MI, stroke, coronary heart disease, CV mortality, all-cause mortality, and bleeding.
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Murff HJ. Review: In adults with diabetes, aspirin does not prevent CV events compared with placebo. Ann Intern Med. 2016;165:JC53. doi: 10.7326/ACPJC-2016-165-10-053

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Published: Ann Intern Med. 2016;165(10):JC53.

DOI: 10.7326/ACPJC-2016-165-10-053

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2016 American College of Physicians
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