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Letters |15 November 2016

Reversal of Alopecia Universalis by Tofacitinib: A Case Report

Morton Scheinberg, MD, PhD; Sineida Berbert Ferreira, MD

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Background: Alopecia universalis involves complete hair loss in all parts of the body (1). It is considered to be an advanced form of alopecia areata, which involves hair loss on some parts of the body, often in sharply demarcated areas. The cause of alopecia universalis is uncertain, but many investigators believe it to be an autoimmune disease with the patient's immune system directed against the hair follicles. In support of this hypothesis, clinical and experimental studies have shown infiltration by T lymphocytes into the immunologically privileged zone around the hair follicle with changes in cytokine and chemokine profiles (2). No treatment is effective for alopecia universalis, although several that have been proposed have variable results, limited efficacy, and adverse effects.
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Scheinberg M, Ferreira SB. Reversal of Alopecia Universalis by Tofacitinib: A Case Report. Ann Intern Med. ;165:750–751. doi: 10.7326/L16-0125

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Published: Ann Intern Med. 2016;165(10):750-751.

DOI: 10.7326/L16-0125

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2016 American College of Physicians
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