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ACP Journal Club |17 January 2017

In adults ≥ 70 years of age, an adjuvanted herpes zoster subunit vaccine reduced herpes zoster at a mean 3.7 years

Henry S. Sacks, PhD, MD

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Cunningham AL, Lal H, Kovac M, et al; ZOE-70 Study Group. Efficacy of the herpes zoster subunit vaccine in adults 70 years of age or older. N Engl J Med. 2016;375:1019-32. 27626517

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Geriatrics:

Infectious Disease:

In adults ≥ 70 years of age, does a herpes zoster subunit (HZ/su) vaccine reduce herpes zoster compared with placebo? Does it reduce postherpetic neuralgia?
Randomized placebo-controlled trial (Zoster Efficacy Study in Adults 70 Years of Age or Older [ZOE-70]) ClinicalTrials.gov NCT01165229. A prespecified pooled analysis of ZOE-70 and a companion trial in adults ≥ 50 years of age (ZOE-50*, ClinicalTrials.gov NCT01165177) was done to assess effects on herpes zoster and postherpetic neuralgia.
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Sacks HS. In adults ≥ 70 years of age, an adjuvanted herpes zoster subunit vaccine reduced herpes zoster at a mean 3.7 years. Ann Intern Med. ;166:JC5. doi: 10.7326/ACPJC-2017-166-2-005

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Published: Ann Intern Med. 2017;166(2):JC5.

DOI: 10.7326/ACPJC-2017-166-2-005

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2017 American College of Physicians
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