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ACP Journal Club |21 March 2017

In patients receiving palliative care, risperidone or haloperidol increased delirium symptoms vs placebo

Justin Lee, BScPhm, MD; Anne Holbrook, MD, PharmD

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Agar MR, Lawlor PG, Quinn S, et al. Efficacy of oral risperidone, haloperidol, or placebo for symptoms of delirium among patients in palliative care: a randomized clinical trial. JAMA Intern Med. 2017;177:34-42. 27918778

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In patients receiving palliative care, does risperidone or haloperidol reduce symptoms of distress-associated delirium compared with placebo?
Randomized placebo-controlled trial (RCT). ACTRN12607000562471.
Concealed.*
Blinded* (patients and investigators).
3 days.
11 inpatient hospice or palliative care services in Australia.
249 adults (mean age 75 y, 65% men, 88% with cancer) who had life-limiting illness, were receiving inpatient hospice or palliative care, had Memorial Delirium Assessment Scale...
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Lee J, Holbrook A. In patients receiving palliative care, risperidone or haloperidol increased delirium symptoms vs placebo. Ann Intern Med. 2017;166:JC32. doi: 10.7326/ACPJC-2017-166-6-032

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Published: Ann Intern Med. 2017;166(6):JC32.

DOI: 10.7326/ACPJC-2017-166-6-032

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2017 American College of Physicians
2 Citations

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