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Letters |18 April 2017

Cost-Effectiveness of Sacubitril–Valsartan in Patients Who Have Heart Failure With Reduced Ejection Fraction

Alexander T. Sandhu, MD, MS; Daniel A. Ollendorf, PhD; Richard H. Chapman, PhD; Steven D. Pearson, MD, MSc; Paul A. Heidenreich, MD, MS

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We agree with Dr. King and colleagues about the importance of the multiple cost-effectiveness analyses of sacubitril–valsartan that have been published (1, 2). The consistency in these findings supports the internal validity of these models that were designed using the PARADIGM-HF trial results (3) but does not strengthen the external validity of these results or the likelihood that these estimates will match real-world cost-effectiveness. Given that this combination therapy is novel, data are not sufficient to estimate real-world effectiveness or indication drift. However, we believe that estimating the value of a treatment early...
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Sandhu AT, Ollendorf DA, Chapman RH, et al. Cost-Effectiveness of Sacubitril–Valsartan in Patients Who Have Heart Failure With Reduced Ejection Fraction. Ann Intern Med. 2017;166:607–608. doi: https://doi.org/10.7326/L17-0044

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Published: Ann Intern Med. 2017;166(8):607-608.

DOI: 10.7326/L17-0044

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2017 American College of Physicians
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