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Letters |20 June 2017

Epinephrine Concentrations in EpiPens After the Expiration Date

F. Lee Cantrell, PharmD; Patricia Cantrell, MD; Anita Wen, BS; Roy Gerona, PhD

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This article was published at Annals.org on 9 May 2017.
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Background: Interest and outrage have been mounting over dramatic price increases for the emergency-use epinephrine autoinjection device EpiPen (Mylan). Since 2007, the price of this potentially lifesaving medication has risen more than 400%. This sharp increase has caused patients to ask health care practitioners whether they can use expired EpiPens because they cannot afford to replace them.
Objective: To determine whether EpiPens expired up to 50 months retain their stated potency.
Methods: Over 2 weeks, patients and practitioners at a community clinic were asked to provide unused, expired EpiPens. All pens were examined for color changes and expiration date. Two...
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Cantrell FL, Cantrell P, Wen A, Gerona R. Epinephrine Concentrations in EpiPens After the Expiration Date. Ann Intern Med. 2017;166:918–919. doi: 10.7326/L16-0612

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Published: Ann Intern Med. 2017;166(12):918-919.

DOI: 10.7326/L16-0612

Published at www.annals.org on 9 May 2017

©
2017 American College of Physicians
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