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ACP Journal Club |19 September 2017

In PCI-treated ACS, switching from aspirin + a newer P2Y12 blocker to aspirin + clopidogrel reduced adverse events

Angela Lowenstern, MD; L. Kristin Newby, MD, MHS

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Cuisset T, Deharo P, Quilici J, et al. Benefit of switching dual antiplatelet therapy after acute coronary syndrome: the TOPIC (timing of platelet inhibition after acute coronary syndrome) randomized study. Eur Heart J. 2017 May 16. [Epub ahead of print]. 28510646

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In patients with an acute coronary syndrome (ACS) who were treated with percutaneous coronary intervention (PCI) and had no adverse events after a month of dual antiplatelet therapy (DAPT) with aspirin plus a newer P2Y12 blocker, does switching to a new DAPT regimen of fixed-dose combination (FDC) aspirin plus clopidogrel reduce bleeding and ischemic events?
Randomized...
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Lowenstern A, Newby LK. In PCI-treated ACS, switching from aspirin + a newer P2Y12 blocker to aspirin + clopidogrel reduced adverse events. Ann Intern Med. 2017;167:JC28. doi: https://doi.org/10.7326/ACPJC-2017-167-6-028

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Published: Ann Intern Med. 2017;167(6):JC28.

DOI: 10.7326/ACPJC-2017-167-6-028

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2017 American College of Physicians
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