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ACP Journal Club |19 December 2017

Guided early deescalation of antiplatelet treatment was noninferior to usual prasugrel care in PCI-treated ACS

Eric R. Bates, MD

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Sibbing D, Aradi D, Jacobshagen C, et al; TROPICAL-ACS Investigators. Guided de-escalation of antiplatelet treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention (TROPICAL-ACS): a randomised, open-label, multicentre trial. Lancet. 2017;390:1747-57. 28855078

Cardiology:

In patients who had percutaneous coronary intervention (PCI) for an acute coronary syndrome (ACS), what are the relative efficacy and safety of guided early deescalation of antiplatelet treatment and usual care with prasugrel for ischemic and bleeding events?
Randomized controlled trial (RCT) (Testing Responsiveness To Platelet Inhibition On Chronic Antiplatelet Treatment For Acute Coronary Syndromes [TROPICAL-ACS] trial). ClinicalTrials.gov NCT01959451; EudraCT 2013-001636-22.
Concealed.*
Blinded* (outcome assessors)....
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Bates ER. Guided early deescalation of antiplatelet treatment was noninferior to usual prasugrel care in PCI-treated ACS. Ann Intern Med. 2017;167:JC69. doi: https://doi.org/10.7326/ACPJC-2017-167-12-069

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Published: Ann Intern Med. 2017;167(12):JC69.

DOI: 10.7326/ACPJC-2017-167-12-069

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2017 American College of Physicians
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