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Letters |2 January 2018

Extracranial Carotid Disease and Effect of Intra-arterial Treatment in Patients With Proximal Anterior Circulation Stroke

Feng Ye, MD; Yu Zhang, MD; Rongrui Tang, MD

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TO THE EDITOR:
Berkhemer and colleagues (1) report a post hoc analysis of MR CLEAN (Multicenter Randomized Clinical trial of Endovascular treatment for Acute ischemic stroke in the Netherlands) and conclude that intra-arterial treatment (IAT) may be at least as effective in patients with extracranial carotid disease (ECD) as in those without this condition. However, we have noted key limitations.
The primary effect variable was adjusted for time from stroke onset to randomization in the study, but we contend that adjusting for median time to reperfusion would have been better because this factor more directly affects the outcome....
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Ye F, Zhang Y, Tang R. Extracranial Carotid Disease and Effect of Intra-arterial Treatment in Patients With Proximal Anterior Circulation Stroke. Ann Intern Med. 2018;168:82–83. doi: 10.7326/L17-0492

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Published: Ann Intern Med. 2018;168(1):82-83.

DOI: 10.7326/L17-0492

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2018 American College of Physicians
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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