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ACP Journal Club |21 August 2018

Guideline: Insufficient evidence for vitamin D and/or calcium to prevent fractures in community-dwelling adults

Angela M. Cheung, MD, PhD, FRCPC

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US Preventive Services Task Force, Grossman DC, Curry SJ, et al. Vitamin D, calcium, or combined supplementation for the primary prevention of fractures in community-dwelling adults: US Preventive Services Task Force recommendation statement. JAMA. 2018;319:1592-9. 29677309

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The benefits and harms of vitamin D or calcium supplements, alone or combined, for primary prevention of incident fractures in community-dwelling adults. It updates the US Preventive Services Task Force (USPSTF) 2013 recommendations.
The USPSTF commissioned a systematic review* that searched MEDLINE, EMBASE/Excerpta Medica, and Cochrane Library (all to Mar 2017), ClinicalTrials.gov, WHO International Clinical Trials Registry, and reference lists for English-language studies comparing vitamin D or calcium supplements, alone or combined, with no treatment, placebo, or alternate dosages for primary prevention of fractures in adults living in the community (not a nursing home or other institutional care setting) without previous fractures or known bone metabolism disorders. Article alerts were monitored for new publications up to Feb 2018. 11 randomized controlled trials (RCTs) met selection criteria. A draft version of the recommendations was publicly posted for comments.
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Cheung AM. Guideline: Insufficient evidence for vitamin D and/or calcium to prevent fractures in community-dwelling adults. Ann Intern Med. ;169:JC15. doi: 10.7326/ACPJC-2018-169-4-015

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Published: Ann Intern Med. 2018;169(4):JC15.

DOI: 10.7326/ACPJC-2018-169-4-015

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2018 American College of Physicians
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