Albert Siu, MD, MSPH; Heather Allore, PhD, MS, MA; Darryl Brown, PhD, MPA; Susan T. Charles, PhD; Matthew Lohman, PhD, MHS
Disclosures: The authors have read and agreed to the statement on authorship and dual commitment, but this work is derived from an evidence report commissioned by AHRQ and AHRQ holds copyright on the original works. Authors not named here have disclosed no conflicts of interest. Disclosures can also be viewed at http://www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-0961.
Corresponding Author: Albert Siu, MD, MSPH, The Brookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, Box 1070, New York, NY 10029; e-mail, firstname.lastname@example.org.
Current Author Addresses: Dr. Siu: The Brookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, Box 1070, New York, NY 10029.
Dr. Allore: Department of Internal Medicine, Section of Geriatrics, Yale School of Medicine, 300 George Street, New Haven, CT 06520-2085.
Dr. Brown: Department of Health Management and Policy, Dornsife School of Public Health, Drexel University, Nesbitt Hall, 3215 Market Street, Third Floor, Philadelphia, PA 19104.
Dr. Charles: Department of Psychological Science, University of California, Irvine, 4326 Social and Behavioral Sciences Gateway, Irvine, CA 92697-7085.
Dr. Lohman: University of South Carolina, Arnold School of Public Health, 915 Greene Street, Discovery Building, Room 440, Columbia, SC 29208.
Author Contributions: Conception and design: A.L. Siu, H. Allore, D. Brown, S.T. Charles, M. Lohman.
Analysis and interpretation of the data: A.L. Siu, H. Allore, D. Brown, S.T. Charles, M. Lohman.
Drafting of the article: A.L. Siu, H. Allore, D. Brown, S.T. Charles, M. Lohman.
Critical revision for important intellectual content: A.L. Siu, H. Allore, D. Brown, S.T. Charles, M. Lohman.
Final approval of the article: A.L. Siu, H. Allore, D. Brown, S.T. Charles, M. Lohman.
Statistical expertise: H. Allore.
Collection and assembly of data: A.L. Siu, H. Allore, D. Brown, S.T. Charles, M. Lohman.
On 30 and 31 October 2018, the National Institutes of Health convened the Pathways to Prevention (P2P) Workshop: Appropriate Use of Drug Therapies for Osteoporotic Fracture Prevention to assess the available evidence on long-term (>3 years) use of drug therapies to prevent osteoporotic fractures and identify research gaps and needs for advancing the field. The workshop was cosponsored by the NIH Office of Disease Prevention (ODP), National Institute of Arthritis and Musculoskeletal and Skin Diseases, and National Institute on Aging. A multidisciplinary working group developed the agenda, and an Evidence-based Practice Center prepared an evidence report through a contract with the Agency for Healthcare Research and Quality to facilitate the discussion. During the 1.5-day workshop, invited experts discussed the body of evidence and attendees had the opportunity to comment during open discussions. After data from the evidence report, expert presentations, and public comments were weighed, an unbiased independent panel prepared a draft report that was posted on the ODP Web site for 5 weeks for public comment. This final report summarizes the panel's findings and recommendations. Current gaps in knowledge are highlighted, and a set of recommendations for new, strengthened research to better inform the long-term use of osteoporotic drug therapies is delineated.
Siu A, Allore H, Brown D, et al. National Institutes of Health Pathways to Prevention Workshop: Research Gaps for Long-Term Drug Therapies for Osteoporotic Fracture Prevention. Ann Intern Med. 2019;171:51–57. [Epub ahead of print 23 April 2019]. doi: 10.7326/M19-0961
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Published: Ann Intern Med. 2019;171(1):51-57.
Published at www.annals.org on 23 April 2019
Emergency Medicine, Endocrine and Metabolism, Metabolic Bone Disorders.
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