Ronald Laracuente, BA; Marc Paul Waase, MD; Isha Kalia, MS; Arthur A.M. Wilde, MD; Wendy K. Chung, MD, PhD
Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Grant Support: This publication was supported by grant UL1TR001873 from the National Center for Advancing Translational Sciences, National Institutes of Health. Mr. Laracuente was supported by T35 grant 5T35HL007616 from the National Heart, Lung, and Blood Institute.
Disclosures: Dr. Wilde had served on a scientific advisory board for Audentes Therapeutics. Authors not named here have disclosed no conflicts of interest. Disclosures can also be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M18-2359.
Editors' Disclosures: Christine Laine, MD, MPH, Editor in Chief, reports that her spouse has stock options/holdings with Targeted Diagnostics and Therapeutics. Darren B. Taichman, MD, PhD, Executive Editor, reports that he has no financial relationships or interests to disclose. Cynthia D. Mulrow, MD, MSc, Senior Deputy Editor, reports that she has no relationships or interests to disclose. Jaya K. Rao, MD, MHS, Deputy Editor, reports that she has stock holdings/options in Eli Lilly and Pfizer. Catharine B. Stack, PhD, MS, Deputy Editor, Statistics, reports that she has stock holdings in Pfizer, Johnson & Johnson, and Colgate-Palmolive. Christina C. Wee, MD, MPH, Deputy Editor, reports employment with Beth Israel Deaconess Medical Center. Sankey V. Williams, MD, Deputy Editor, reports that he has no financial relationships or interests to disclose. Yu-Xiao Yang, MD, MSCE, Deputy Editor, reports that he has no financial relationships or interest to disclose.
Corresponding Author: Wendy K. Chung, MD, PhD, Columbia University Medical Center, 1150 St. Nicholas Avenue, Room 620, New York, NY 10032; e-mail, firstname.lastname@example.org.
Current Author Addresses: Mr. Laracuente: 424 West 160th Street, Unit 2, New York, NY 10032.
Dr. Waase: Columbia University Medical Center, 622 West 168th St, PH10-203, New York, NY 10032.
Ms. Kalia: Columbia University Irving Medical Center, 622 West 168th Street, PH10-305, New York, NY 10032.
Dr. Wilde: Heart Centre AMC, Academic Medical Centre, University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.
Dr. Chung: Columbia University Medical Center, 1150 St. Nicholas Avenue, Room 620, New York, NY 10032.
Author Contributions: Conception and design: R. Laracuente, M.P. Waase, I. Kalia, A.A.M. Wilde, W.K. Chung.
Drafting of the article: R. Laracuente, M.P. Waase, I Kalia, W.K. Chung.
Critical revision for important intellectual content: R. Laracuente, M.P. Waase, I Kalia, A.A.M. Wilde, W.K. Chung.
Final approval of the article: R. Laracuente, M.P. Waase, I. Kalia, A.A.M. Wilde, W.K. Chung.
Obtaining of funding: R. Laracuente, W.K. Chung.
Administrative, technical, or logistic support: W.K. Chung.
Sudden death in a family is associated with serious anxiety among family members. Assessing the cause of death may help determine the risk for other family members, thus alleviating some anxiety. In some cases, the cause of death may be evident on autopsy; however, in cases of arrhythmias, standard autopsy will not reveal the cause of death. Evaluation of the circumstances of death, medical history of the deceased, and results of genetic testing may reveal a diagnosis. Once a diagnosis is made, relatives should receive genetic testing and clinical assessment to stratify their risk. Depending on their risk, various interventions are available, including medication, defibrillators, and lifestyle modifications.
Laracuente R, Waase MP, Kalia I, Wilde AA, Chung WK. Cases in Precision Medicine: Genetic Assessment After a Sudden Cardiac Death in the Family. Ann Intern Med. 2019;170:710–716. doi: 10.7326/M18-2359
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Published: Ann Intern Med. 2019;170(10):710-716.
Published at www.annals.org on 14 May 2019
Cardiology, Prevention/Screening, Rhythm Disorders and Devices.
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