Bohan Lin, BA; Wendy K. Chung, MD, PhD
Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Grant Support: By the National Center for Advancing Translational Sciences, National Institutes of Health (grant UL1TR001873).
Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M18-2357.
Editors' Disclosures: Christine Laine, MD, MPH, Editor in Chief, reports that her spouse has stock options/holdings with Targeted Diagnostics and Therapeutics. Darren B. Taichman, MD, PhD, Executive Editor, reports that he has no financial relationships or interests to disclose. Cynthia D. Mulrow, MD, MSc, Senior Deputy Editor, reports that she has no relationships or interests to disclose. Jaya K. Rao, MD, MHS, Deputy Editor, reports that she has stock holdings/options in Eli Lilly and Pfizer. Catharine B. Stack, PhD, MS, Deputy Editor, Statistics, reports that she has stock holdings in Pfizer, Johnson & Johnson, and Colgate-Palmolive. Christina C. Wee, MD, MPH, Deputy Editor, reports employment with Beth Israel Deaconess Medical Center. Sankey V. Williams, MD, Deputy Editor, reports that he has no financial relationships or interests to disclose. Yu-Xiao Yang, MD, MSCE, Deputy Editor, reports that he has no financial relationships or interest to disclose.
Corresponding Author: Wendy K. Chung, MD, PhD, Columbia University Medical Center, 1150 St. Nicholas Avenue, Room 620, New York, NY 10032; e-mail, firstname.lastname@example.org.
Current Author Addresses: Mr. Lin: 618 West 164th Street, New York, NY 10032.
Dr. Chung: Columbia University Medical Center, 1150 St. Nicholas Avenue, Room 620, New York, NY 10032.
Author Contributions: Conception and design: W.K. Chung.
Analysis and interpretation of the data: B. Lin.
Drafting of the article: B. Lin, W.K. Chung.
Critical revision for important intellectual content: W.K. Chung.
Final approval of the article: B. Lin, W.K. Chung.
Obtaining of funding: W.K. Chung.
Administrative, technical, or logistic support: W.K. Chung.
Collection and assembly of data: B. Lin, W.K. Chung.
Pharmacogenetics may help physicians deliver individualized treatments based on how a person's genes affect a drug's effects and metabolism. This information can help prevent adverse events or improve drug efficacy by enabling the physician to optimize dosage or to avoid a medication with adverse reactions and to prescribe an alternative therapy. This article discusses the current clinical utility of pharmacogenetic testing in the context of a patient who requires anticoagulation with warfarin.
Lin B, Chung WK. Cases in Precision Medicine: The Role of Pharmacogenetics in Precision Prescribing. Ann Intern Med. [Epub ahead of print 21 May 2019]170:796–804. doi: 10.7326/M18-2357
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Published: Ann Intern Med. 2019;170(11):796-804.
Published at www.annals.org on 21 May 2019
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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