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Letters |2 July 2019

Fracture Risk After Initiation of Use of Canagliflozin

Hema Padmanabhan, MD

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TO THE EDITOR:
Fralick and colleagues (1) conclude that canagliflozin is not associated with a higher risk for fracture than a glucagon-like peptide-1 (GLP-1) agonist in middle-aged patients with type 2 diabetes mellitus and an otherwise relatively low fracture risk. Their data may not provide a full picture of canagliflozin's effect on bones, thus making this conclusion less reliable.
The patient population in their cohort study was relatively young, which reduces their risk for fracture. The large number of men in this study also may have affected the results. Postmenopausal women are at greater risk for bone loss...
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Padmanabhan H. Fracture Risk After Initiation of Use of Canagliflozin. Ann Intern Med. 2019;171:79–80. doi: 10.7326/L19-0319

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Published: Ann Intern Med. 2019;171(1):79-80.

DOI: 10.7326/L19-0319

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2019 American College of Physicians
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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