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ACP Journal Club |16 July 2019

In CVD, continuing vs interrupting clopidogrel before colonoscopy did not differ for delayed postpolypectomy bleeding

David Lichtenstein, MD; Abhinav Vemula, MD

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Chan FK, Kyaw MH, Hsiang JC, et al. Risk of postpolypectomy bleeding with uninterrupted clopidogrel therapy in an industry-independent, double-blind, randomized trial. Gastroenterology. 2019;156:918-25.e1. 30518511

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Gastroenterology:

In patients with cardiovascular (CV) disease who are receiving clopidogrel, does drug continuation vs interruption before colonoscopy increase postpolypectomy bleeding at 30 days?
Randomized placebo-controlled trial (Clopidogrel Uninterrupted Postpolypectomy Bleeding [CUP] trial). ClinicalTrials.gov NCT01806090.
{Concealed}*.†
Blinded† (patients, outcome adjudication committee, {pathologists, and endoscopists}*).
30 days (primary outcome) and 6 months.
Prince of Wales Hospital of The Chinese University of Hong Kong, Hong Kong, China.
423 patients who were receiving clopidogrel and needed colonoscopy...
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Lichtenstein D, Vemula A. In CVD, continuing vs interrupting clopidogrel before colonoscopy did not differ for delayed postpolypectomy bleeding. Ann Intern Med. 2019;171:JC6. doi: 10.7326/ACPJ201907160-006

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Published: Ann Intern Med. 2019;171(2):JC6.

DOI: 10.7326/ACPJ201907160-006

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2019 American College of Physicians
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