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ACP Journal Club |17 September 2019

In patients ≥ 50 years with type 2 diabetes and CV disease or risk factors, dulaglutide reduced CV outcomes

Lorraine L. Lipscombe, MD, MSc

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Gerstein HC, Colhoun HM, Dagenais GR, et al; REWIND Investigators. Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial. Lancet. 2019;394:121-30. 31189511

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Cardiology:

Endocrinology:

In patients ≥ 50 years of age with type 2 diabetes and previous cardiovascular (CV) disease or risk factors, does dulaglutide reduce risk for CV events?
Randomized placebo-controlled trial (Researching Cardiovascular Events with a Weekly Incretin in Diabetes [REWIND] trial). ClinicalTrials.gov NCT01394952.
Concealed.*
Blinded* (patients, {clinicians, data collectors, and outcome adjudicators}†).
Median 5.4 years.
371 clinical centers in 24 countries.
9901 adults ≥ 50 years of age (mean age 66...
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Lipscombe LL. In patients ≥ 50 years with type 2 diabetes and CV disease or risk factors, dulaglutide reduced CV outcomes. Ann Intern Med. 2019;171:JC27. doi: https://doi.org/10.7326/ACPJ201909170-027

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Published: Ann Intern Med. 2019;171(6):JC27.

DOI: 10.7326/ACPJ201909170-027

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2019 American College of Physicians
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