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Letters |17 September 2019

Polyclonal Staphylococcus aureus Bacteremia

Aleksandra Petrovic Fabijan; Nouri L. Ben Zakour; Josephine Ho; Ruby C.Y. Lin; Jonathan Iredell, PhD; for the Westmead Bacteriophage Therapy Team (WBTT) and AmpliPhi Biosciences Corporation *

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
This article was published at Annals.org on 17 September 2019.
* For members of the WBTT and AmpliPhi Biosciences Corporation, see the  Appendix.
  • Westmead Institute for Medical Research and Westmead Hospital of Western Sydney Local Health District, Sydney, Australia (A.P.F., J.H.)
    Westmead Institute for Medical Research and University of Sydney School of Medicine, Sydney, Australia (N.L.B.)
    Westmead Institute for Medical Research, Westmead Hospital of Western Sydney Local Health District, University of Sydney School of Medicine, and University of New South Wales School of Medical Sciences, Sydney, Australia (R.C.L.)
    Westmead Institute for Medical Research, Westmead Hospital of Western Sydney Local Health District, and University of Sydney School of Medicine, Sydney, Australia (J.I.)

    Acknowledgment: The authors thank Joey Lai and Li Ma at Westmead Institute for Medical Research and the staff of the Pathogen Genomics Unit at Westmead Hospital and Ramaciotti Centre (University of New South Wales) for technical advice and sequencing support; Angela Netluch and Patricia Fa for pharmacy support; Stephanie Chan, Katherine Garnham, Sonya Natasha Hutabarat, Cecilia Li, Chris Robson, Andrew Ginn, and the staff of the New South Wales Pathology Microbiology laboratory at Westmead Hospital for help with data and sample collection; and Bethany Bowring for laboratory assistance.

    Financial Support: ABPH provided the investigational product AB-SA01 and partial financial support for work carried out at Western Sydney Local Health District and Westmead Institute for Medical Research to treat patients and analysis of samples, as investigator-led research sponsored and indemnified by Western Sydney Local Health District. Dr. Iredell is supported by grants 1104232 and 1107322 from the Australian National Health and Medical Research Council.

    Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L19-0369.

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Background: Polyclonal, coagulase-negative staphylococci are common contaminants of blood cultures (1), but polyclonal, coagulase-positive staphylococci (Staphylococcus aureus) have yet to be unambiguously identified as a cause of bacteremia.
Objective: To describe a patient with simultaneous and persistent bacteremia from 2 strains of S aureus.
Case Report: A 36-year-old woman who used intravenous drugs was hospitalized in May 2018 for chest pain and fever. She was known to be infected with hepatitis B and C viruses. Blood cultures isolated methicillin-susceptible S aureus (Table and Figure), transthoracic echocardiography identified a vegetation on the septal leaflet...
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Fabijan AP, Ben Zakour NL, Ho J, et al, for the Westmead Bacteriophage Therapy Team (WBTT) and AmpliPhi Biosciences Corporation. Polyclonal Staphylococcus aureus Bacteremia. Ann Intern Med. 2019;:. [Epub ahead of print 17 September 2019]. doi: https://doi.org/10.7326/L19-0369

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Published: Ann Intern Med. 2019.

DOI: 10.7326/L19-0369

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2019 American College of Physicians
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