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Letters |15 October 2019

Fanconi Syndrome and Tenofovir Alafenamide

Hortensia Álvarez, MD; Josep M. Llibre, MD, PhD

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TO THE EDITOR:
Some issues in Bahr and colleagues' (1) case report on a patient with Fanconi syndrome caused by tenofovir alafenamide (TAF) warrant further investigation. The authors state that theirs is the fourth report of kidney toxicity due to TAF and list 3 previous cases. We disagree.
One case was an intentional overdose of elvitegravir–cobicistat–emtricitabine-TAF that we reported (2). However, we ultimately determined that this patient had no tubular toxicity despite the TAF overdose. The estimated cumulative dose of TAF was approximately 30 times higher than with usual exposure to these agents. Acute tubular necrosis...
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Álvarez H, Llibre JM. Fanconi Syndrome and Tenofovir Alafenamide. Ann Intern Med. 2019;171:598–599. doi: https://doi.org/10.7326/L19-0476

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Published: Ann Intern Med. 2019;171(8):598-599.

DOI: 10.7326/L19-0476

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2019 American College of Physicians
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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