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ACP Journal Club |19 November 2019

Review: In multiepisode schizophrenia, most antipsychotic drugs improve symptoms; adverse effects vary by drug

Brian Budenholzer, MD

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Huhn M, Nikolakopoulou A, Schneider-Thoma J, et al. Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis. Lancet. 2019;394:939-51. 31303314

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In adults with multiepisode schizophrenia, how do oral antipsychotic drugs compare for acute treatment?
Included studies compared first- or second-generation antipsychotic drugs with placebo or another first- or second-generation antipsychotic drug in adults with symptoms of acute schizophrenia or related disorders. Exclusion criteria included a first disorder episode, treatment-resistant disorders, episodes with mainly negative or depressive symptoms, presence of comorbid medical conditions, intramuscular...
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Budenholzer B. Review: In multiepisode schizophrenia, most antipsychotic drugs improve symptoms; adverse effects vary by drug. Ann Intern Med. 2019;171:JC57. doi: https://doi.org/10.7326/ACPJ201911190-057

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Published: Ann Intern Med. 2019;171(10):JC57.

DOI: 10.7326/ACPJ201911190-057

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2019 American College of Physicians
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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