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ACP Journal Club |19 November 2019

Orally disintegrating rimegepant increased freedom from pain and from most bothersome symptom at 2 h in acute migraine

Lucas McCarthy, MD, MS

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Croop R, Goadsby PJ, Stock DA, et al. Efficacy, safety, and tolerability of rimegepant orally disintegrating tablet for the acute treatment of migraine: a randomised, phase 3, double-blind, placebo-controlled trial. Lancet. 2019;394:737-45. 31311674

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Neurology:

In patients with acute migraine, what are the efficacy and safety of an orally disintegrating tablet (ODT) of rimegepant?
Randomized placebo-controlled trial. ClinicalTrials.gov NCT03461757.
Concealed.*
Blinded* {patients, clinicians, data collectors, data analysts, and sponsor}†.
Up to 7 days after treatment.
69 clinical centers in the USA.
1466 adults (mean age 40 y, 85% women) who had a history of migraine with or without aura for...
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McCarthy L. Orally disintegrating rimegepant increased freedom from pain and from most bothersome symptom at 2 h in acute migraine. Ann Intern Med. 2019;171:JC58. doi: https://doi.org/10.7326/ACPJ201911190-058

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Published: Ann Intern Med. 2019;171(10):JC58.

DOI: 10.7326/ACPJ201911190-058

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2019 American College of Physicians
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