Joshua Elliott Rubin, MD; Sheila E. Crowe, MD
CME Objective: To review current evidence for prevention, screening, diagnosis, treatment, and patient education of celiac disease.
Funding Source: American College of Physicians.
Disclosures: Dr. Rubin, ACP Contributing Author, reports personal fees from RMEI Medical Education outside the submitted work. Dr. Crowe, ACP Contributing Author, reports grants from the National Institutes of Health and the University of California, San Diego, during the conduct of the study; personal fees from Takeda and Calypso Biotech during the conduct of the study; grants and other support from the University of California, San Diego, outside the submitted work; and a pending patent for biomarkers to stratify different clinical presentations of celiac disease. Disclosures can also be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-2234.
Editors' Disclosures: Christine Laine, MD, MPH, Editor in Chief, reports that her spouse has stock options/holdings with Targeted Diagnostics and Therapeutics. Darren B. Taichman, MD, PhD, Executive Editor, reports that he has no financial relationships or interests to disclose. Cynthia D. Mulrow, MD, MSc, Senior Deputy Editor, reports that she has no relationships or interests to disclose. Jaya K. Rao, MD, MHS, Deputy Editor, reports that she has stock holdings/options in Eli Lilly and Pfizer. Christina C. Wee, MD, MPH, Deputy Editor, reports employment with Beth Israel Deaconess Medical Center. Sankey V. Williams, MD, Deputy Editor, reports that he has no financial relationships or interests to disclose. Yu-Xiao Yang, MD, MSCE, Deputy Editor, reports that he has no financial relationships or interest to disclose.
With the assistance of additional physician writers, the editors of Annals of Internal Medicine develop In the Clinic using MKSAP and other resources of the American College of Physicians.
The Patient Information page was written by Monica Lizarraga from the Patient and Interprofessional Education Program at the American College of Physicians.
In the Clinic does not necessarily represent official ACP clinical policy. For ACP clinical guidelines, please go to https://www.acponline.org/clinical_information/guidelines/.
Gluten-related disorders, including celiac disease, wheat allergy, and nonceliac gluten sensitivity (NCGS), are increasingly reported worldwide. Celiac disease is caused by an immune-mediated reaction to ingested gluten in genetically susceptible persons. NCGS is largely a diagnosis of exclusion when other causes of symptoms have been ruled out. All patients with celiac disease should be referred to a registered dietitian nutritionist with expertise in celiac disease and a gastroenterologist who specializes in celiac disease and malabsorptive disorders, and they should remain on a strict gluten-free diet indefinitely. This article provides an overview of gluten- and wheat-related disorders.
Rubin JE, Crowe SE. Celiac Disease. Ann Intern Med. 2020;172:ITC1–ITC16. doi: https://doi.org/10.7326/AITC202001070
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Published: Ann Intern Med. 2020;172(1):ITC1-ITC16.
Celiac Disease and Malabsorption, Gastroenterology/Hepatology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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