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ACP Journal Club |20 September 2011

Review: Oral phosphodiesterase 4 inhibitors reduce exacerbations but increase adverse events in COPD

Felix S.F. Ram, PhD, Clinical Pharmacologist

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Chong J, Poole P, Leung B, Black PN. Phosphodiesterase 4 inhibitors for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2011;(5):CD002309. 21563134

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Pulmonology:

PDEs are cAMP- or cGMP-specific enzymes that are ubiquitous in humans. Of particular interest is the PDE4 isoenzyme, which hydrolyzes cAMP and is expressed in structural cells of the lung (such as smooth muscle cells and airway epithelium) and inflammatory cells (such as neutrophils, lymphocytes, or macrophages). The systematic review and meta-analysis by Chong and colleagues assessed 12 to 52 weeks of treatment with PDE4 inhibitors (roflumilast and cilomilast) as add-on therapy in COPD....
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Ram FS. Review: Oral phosphodiesterase 4 inhibitors reduce exacerbations but increase adverse events in COPD. Ann Intern Med. 2011;155:JC3–2. doi: 10.7326/0003-4819-155-6-201109200-02002

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Published: Ann Intern Med. 2011;155(6):JC3-2.

DOI: 10.7326/0003-4819-155-6-201109200-02002

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