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ACP Journal Club |20 September 2011

Raloxifene increased bone mineral density in the spine and hips of postmenopausal women using long-term glucocorticoids

John Robbins, MD

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Mok CC, Ying KY, To CH, et al. Raloxifene for prevention of glucocorticoid-induced bone loss: a 12-month randomised double-blinded placebo-controlled trial. Ann Rheum Dis. 2011;70:778-84. 21187295

Endocrinology:

Rheumatology:

Mok and colleagues clearly reported what they set out to do and what they achieved. Raloxifene prevented BMD loss in postmenopausal women with rheumatologic diseases who were receiving long-term steroid treatment. Fracture outcomes and side effects were also reported, but the study lacked power to evaluate those outcomes.
We know that long-term steroid use increases risk for fractures. In a case–control study of 488 570 patients, van Staa and colleagues showed that...
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Robbins J. Raloxifene increased bone mineral density in the spine and hips of postmenopausal women using long-term glucocorticoids. Ann Intern Med. 2011;155:JC3–4. doi: 10.7326/0003-4819-155-6-201109200-02004

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Published: Ann Intern Med. 2011;155(6):JC3-4.

DOI: 10.7326/0003-4819-155-6-201109200-02004

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