EDGAR V. ALLEN, M.D.; GEORGE E. BROWN, M.D.
Spontaneous gangrene of the feet in middle-aged patients without arteriosclerosis has been known for many years. In 1879 Winiwarter reported the case of a man, aged fifty-seven, who had complained of rheumatic pains in the feet for twelve years. The pathologic changes were intimal proliferation, thrombosis and periarterial fibrosis; arteriosclerosis was absent. He designated the condition as a peculiar type of endarteritis and endophlebitis. Weiss, in 1895, and Manteuffel, in 1897, reported similar cases from which they concluded that the thrombosis was due to intimal changes of an arteriosclerotic nature. In 1879 Borchard reported five cases and favored the view
ALLEN EV, BROWN GE. Thrombo-Angiitis Obliterans: A Clinical Study of 200 Cases1: I. Etiology, Pathology, Symptoms, Diagnosis. Ann Intern Med. ;1:535–549. doi: 10.7326/0003-4819-1-8-535
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Published: Ann Intern Med. 1928;1(8):535-549.
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