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Knowledge concerning gallstones is just emerging from the observation stage. Experiment has shown that the calculi developing out of the bile of laboratory animals differ essentially in their constitution from human gallstones. It is the human problem that is important; and it might seem that animal experimentation on gallstones is a waste of time, were it not for the fact that human biliary calculi are to a very large extent the product of physiological activities that can be studied advantageously in animals. These physiological activities are the constants of the gallstone situation as contrasted with the variables such as infection
Physiological Factors in the Genesis of Gallstones. Fourth Ludvig Hektoen Lecture on the Billings Foundation.. Ann Intern Med. ;1:846–847. doi: 10.7326/0003-4819-1-10-846
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Published: Ann Intern Med. 1928;1(10):846-847.
Biliary Disorders, Gastroenterology/Hepatology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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