This content is PDF only. Please click on the PDF icon to access.
This investigation on the inhibitory effect of blood on insulin activity was incited by the study in 1925 of a diabetic child with refractory periods to insulin. The work was done with rabbits. One physiologic or 3 clinical units of insulin were mixed with the substance investigated and incubated at 37° C. from 1 to 2 hours, then injected subcutaneously into rabbits weighing 2 kilos, starved during the preceding 24 hours. Hourly blood sugar determination and clinical observations were made. The results summarized were as follows: 2-4 cc. of human plasma caused hardly any inhibition of insulin action; 5 cc.
Studies on Inhibition of Insulin Activity.. Ann Intern Med. 1928;2:578. doi: 10.7326/0003-4819-2-6-578_1
Download citation file:
Published: Ann Intern Med. 1928;2(6):578.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use