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The nature of the syphilitic blood change is still under discussion two decades after its discovery, as shown by the varying theories still supported by different groups of investigators. Three principal theories at present are: the physical-chemical theory, according to which its demonstration by means of organ-extracts is not an antigen-antibody reaction but a colloidal reaction between serum-colloids and extract colloids; the autoantibody theory which regards the cause of the alteration of the blood as due to the appearance of reaction-products against the body's own organ-lipoids; and the theory that the syphilitic blood change is an immune reaction against the
Die Syphilitische Blutvera̋nderung.. Ann Intern Med. 1928;2:578–579. doi: https://doi.org/10.7326/0003-4819-2-6-578_2
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Published: Ann Intern Med. 1928;2(6):578-579.
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