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The preparation "acoin," chemically alkyloxyphenylguanidin, prepared by the firm of Heyden, has been used in the treatment of diabetes by Izar, Cannavo and Scuderi, on account of its guanidin components. They reported that in three cases its use produced a lowering of glycosuria and of acidosis, but without effect on the bloodsugar. Voigt treated nine cases of diabetes with acoin. The drug was given in doses of three tablets three times daily, about 0.45 g. With the exception of the bad taste the drug was well borne. No influence was noted either on the glycosuria or acidosis, nor on the
Diabetes Therapie mit Acoin.. Ann Intern Med. 1929;2:693. doi: 10.7326/0003-4819-2-7-693_2
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Published: Ann Intern Med. 1929;2(7):693.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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