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Högler reports two cases in which the insulin cure was interrupted because of the appearance of a temporary hyperthyroidism, with symptoms of tachycardia, fine tremors, damp skin and maniacal condition of excitement with an increased basal metabolism. After the cessation of the insulin the hyperthyroid symptoms disappeared and the basal metabolism fell to the normal. The production of the basedowian symptoms through insulin points to a correlation between thyroid and islands of Langerhans. Even under normal conditions may any overproduction of insulin produce a certain increased activity on the part of the thyroid. One may suppose that with very labile
Über das Auftreten von temporärem Hyperthyroidismus während der Insulinkur.. Ann Intern Med. 1929;2:974–975. doi: https://doi.org/10.7326/0003-4819-2-9-974
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Published: Ann Intern Med. 1929;2(9):974-975.
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