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By activation of insulin one understands a strengthening and a prolongation of its antidiabetic effect through different means. Bertram mixed insulin with albumin bodies, with casaeosan and human serum. The intramuscular injection of the mixture produced in diabetic and in normal rabbits a definite strengthening and prolongation of the lowering of the blood sugar. In further experiments Vogt has produced similar results through the injection of aolan and novoprotin. The most marked effect was produced through the use of the diabetics own serum. Very important is the fact that the activation occurs only in intramuscular injections, but not after intravenous.
Ueber die Aktivierung des Insulins bei Nichtdiabetischen.. Ann Intern Med. 1929;2:976–977. doi: https://doi.org/10.7326/0003-4819-2-9-976
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Published: Ann Intern Med. 1929;2(9):976-977.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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