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It has been thoroughly established that digitalis diminishes the cardiac output of normal animals. Recent observers have attributed this to a direct cardiac action of digitalis, but earlier workers showed that the action on the peripheral vessels was of greater importance. The relationship of the vascular changes to cardiac output in intact animals has not been clearly established or appreciated. Dock and Tainter have measured the cardiac output of dogs by the Tick and cardiometric methods, and have also observed the changes in arterial pressures, and peripheral organ volumes. Full therapeutic doses of digitalis produce the following changes in the
The Circulatory Changes Following Full Therapeutic Doses of Digitalis.. Ann Intern Med. 1929;3:74. doi: https://doi.org/10.7326/0003-4819-3-1-74_2
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Published: Ann Intern Med. 1929;3(1):74.
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