GEORGE R. COWGILL
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Much of the support for the vitamin hypothesis has come from the experimental laboratory of students of nutrition. The pioneer work in this field, however, had a clinical origin centering around the disease beri-beri. In his monographic study of this disorder Vedder (1913) championed the idea that the primary etiologic factor is lack of a vitamin substance. Many clinicians, however, especially among the Japanese (Ogato et al, 1923) hesitate to concur in this opinion, because experimental beri-beri in animals differs in certain respects from human beri-beri as seen in the clinic. Whereas the experimentally produced condition may be due to
COWGILL GR. Some Physiological and Biochemical Aspects of Deficiencies with Special Reference to Vitamin B1. Ann Intern Med. 1929;3:230–241. doi: 10.7326/0003-4819-3-3-230
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Published: Ann Intern Med. 1929;3(3):230-241.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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