GEORGE R. COWGILL
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Much of the support for the vitamin hypothesis has come from the experimental laboratory of students of nutrition. The pioneer work in this field, however, had a clinical origin centering around the disease beri-beri. In his monographic study of this disorder Vedder (1913) championed the idea that the primary etiologic factor is lack of a vitamin substance. Many clinicians, however, especially among the Japanese (Ogato et al, 1923) hesitate to concur in this opinion, because experimental beri-beri in animals differs in certain respects from human beri-beri as seen in the clinic. Whereas the experimentally produced condition may be due to
COWGILL GR. Some Physiological and Biochemical Aspects of Deficiencies with Special Reference to Vitamin B*. Ann Intern Med. 1929;3:230–241. doi: https://doi.org/10.7326/0003-4819-3-3-230
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Published: Ann Intern Med. 1929;3(3):230-241.
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