ROBERT A. COOKE
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I thought it might be interesting to present, together with some illustrative cases, a type of hypersensitive reaction in man that has been little appreciated and is not well understood. The usual clinical conditions of asthma and hay fever are, generally speaking, immediate reactions; that is, the attack is precipitated very quickly within from one to thirty minutes after contact with the substance to which sensitiveness exists. In these cases the diagnostic skin test with this substance is also immediately positive, giving the typical urticarial wheal. It is in this group with the immediate clinical + test reactions that the
COOKE RA. The Delayed Type of Allergic Reaction*. Ann Intern Med. 1930;3:658–661. doi: https://doi.org/10.7326/0003-4819-3-7-658
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Published: Ann Intern Med. 1930;3(7):658-661.
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