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Collens and Murlin have recently reported that the portal injection of insulin into dogs, in dosage of 0.05 to 0.1 unit per kilo weight, results in an immediate sharp rise of blood sugar of 20 to 80 mg. The rise occurs within 5 minutes and is then followed by a rapid decline. No such rise occurs following the systemic injection of the same dose of insulin. About the same time Bűrger and Kramer reported that the injection of 10-20 units of insulin into the cubital vein of human beings produces a rise of blood sugar averaging 11.5%; intrajugular injection of
The So-Called Hyperglycemic Action of Insulin.. Ann Intern Med. 1930;3:868. doi: https://doi.org/10.7326/0003-4819-3-8-868_1
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Published: Ann Intern Med. 1930;3(8):868.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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