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Proliferation of cells is the common defining characteristic of all malignant growth. It follows then that the problem of malignancy centers itself primarily on the processes of cell reproduction. The question of inciting agents is secondary, since all these produce but one biologic reaction, namely, cell proliferation. Once the chain of reactions leading to increase in cell number has been set off in a receptive field, further development depends on the intrinsic biologic characteristics of the tissue in which the growth is taking place, regardless of the nature of the agent which upsets the previ ously existing equilibrium. It is
An Interpretation of Malignant Growth Based on the Chemistry of Cell Division.. Ann Intern Med. 1930;3:947–948. doi: 10.7326/0003-4819-3-9-947_2
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Published: Ann Intern Med. 1930;3(9):947-948.
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