FRANK SMITHIES, M.D., Sc.D.
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In the course of general medical practice, during the past nine years, there has come under my observation a group of patients affected with digestive disorders and chronic skin lesions. In all patients, the dermatoses were of long duration and, in spite of most skillful care by specialists, had become unsightly, and, not rarely, deforming. Frequently enough, the skin lesions were as distressing to the patients as were their dyspeptic upsets.
From the digestive standpoint, the disturbance was of the type colloquially styled "biliousness," manifested either constantly or at intervals. In character, the clinical or pathologic aspects of these ailments
SMITHIES F. Defective Liver Function As a Cause of Chronic Endogenous Skin Lesions1. Ann Intern Med. ;3:1201–1240. doi: 10.7326/0003-4819-3-12-1201
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Published: Ann Intern Med. 1930;3(12):1201-1240.
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