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Since the experimental work of Stoll and Spiro, Löffler, Abderhalden, and Wertheimer showed the action of ergotamin to be antagonistic to the sympathetic and to the action of thyroxin, many workers have employed this substance in the treatment of exophthalmic goiter, with contradictory results. Platt reports the effects of ergotamin administration to three cases of Basedow's disease. He concludes from his observations that the published experiences with this drug in the treatment of exophthalmic goiter are contradictory, and do not take into consideration the effect of rest in bed and the psychical factors. Platt saw no significant improvement that could
On the Treatment of Exophthalmic Goiter with Ergotamin.. Ann Intern Med. 1930;3:1292–1293. doi: https://doi.org/10.7326/0003-4819-3-12-1292_3
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Published: Ann Intern Med. 1930;3(12):1292-1293.
Endocrine and Metabolism, Thyroid Disorders.
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