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Since the isolation by Abel of the active principle of the suprarenal gland in 1897, this substance has been widely used as a vaso-constrictor and hemostatic agent. These properties naturally suggested that the active principle, epinephrin, might have a destructive effect upon certain types of neoplasm. In 1910, Reicher reported that the injection of adrenalin in the neighborhood of rat sarcoma and mouse carcinoma caused a central necrosis and subsequent destruction of these tumors. Uhlenhuth, Haendel, and Steffenhagen found that the local application of adrenalin had very little therapeutic effect on rat sarcoma. On the other hand, Lumsden and Stephens
THE INFLUENCE OF SUPRARENALIN (EPINEPHRIN) ON THE GROWTH OF CARCINOMA AND SARCOMA IN ANIMALS.. Ann Intern Med. 1930;4:638–639. doi: https://doi.org/10.7326/0003-4819-4-6-638
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Published: Ann Intern Med. 1930;4(6):638-639.
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