JAMES F. WEIR, M.D.; WALLACE T. PARTCH, M.D.
In the last decade certain adjustments have been made in our conception of jaundice. This has been due largely to the application by van den Bergh of Ehrlich's diazo reagent to the blood serum and to the demonstration by Mann and his associates, and others, that bilirubin forms chiefly outside the liver and that the polygonal hepatic cell is the normal pathway of excretion of bilirubin. Jaundice may be produced in one of three ways: obstruction of the biliary passages, increased production of bilirubin beyond the ability of the liver to excrete it, or functional derangement of the polygonal hepatic
WEIR JF, PARTCH WT. The Relationship of Pain to Jaundice*. Ann Intern Med. 1931;4:1509–1520. doi: https://doi.org/10.7326/0003-4819-4-12-1509
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Published: Ann Intern Med. 1931;4(12):1509-1520.
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