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By the intramuscular injection of an oily suspension of bismuth hydroxide the authors were able to produce in young rabbits evidences of acute, sub-acute, and chronic nephritis with azotemia, albuminuria, and tubular lesions in the kidneys. The suspension used contained the bismuth compound in an amount equivalent to 0.0646 grams of metallic bismuth per cubic centimeter. The doses employed in the production of nephritis were from 8 to 17 times greater than those used therapeutically in man. With the introduction of 0.50 cc. daily, per kilo of rabbit, all the animals used showed an azotemia which was independent of malnutrition.
Experimental Production of Acute and Chronic Nephritis by the Injection of Bismuth Compounds.. Ann Intern Med. 1931;4:1612–1613. doi: https://doi.org/10.7326/0003-4819-4-12-1612_2
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Published: Ann Intern Med. 1931;4(12):1612-1613.
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