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Under normal conditions the gall bladder mucosa, in its concentrating effect upon the bile, is able to absorb water rapidly; while bile salts and cholesterol, if they are absorbed at all, are absorbed at an equal rate. Under such conditions there is no danger that there will not be enough bile salts to hold the cholesterol in solution. In a series of experiments in which the cystic duct was ligated, leading to infection of the gall bladder, with added traumatic insult, the action was diametrically opposite in respect to differential absorption. In every case an increase in the concentration of
The Etiology of Gall Stones. II. Rôle of the Gall Bladder.. Ann Intern Med. 1931;5:524. doi: https://doi.org/10.7326/0003-4819-5-4-524_2
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Published: Ann Intern Med. 1931;5(4):524.
Biliary Disorders, Gastroenterology/Hepatology.
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