FRANK A. HARTMAN, A.M.,Ph.D.; BYRON D. BOWEN, M.D., F.A.C.P.; GEO. W. THORN, M.D.; CLAYTON W. GREENE, M.D., F.A.C.P.
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It has been known for many years that the adrenal glands are essential to life; but Wheeler and Vincent were the first to prove, at least in mammals, that the medulla was not essential. They found that as long as an adequate amount of cortex survived, destruction of all of the medullary tissue led to no ill effects.
The next step in the study of the cortex was the preparation of an extract containing the hormone. The cortex contains a sufficient amount of epinephrin to make the removal of the latter necessary, especially if the extract is to be concentrated.
HARTMAN FA, BOWEN BD, THORN GW, GREENE CW. The Vital Hormone of the Adrenal Cortex12. Ann Intern Med. ;5:539–551. doi: 10.7326/0003-4819-5-5-539
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Published: Ann Intern Med. 1931;5(5):539-551.
Adrenal Disorders, Endocrine and Metabolism.
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