JOSEPH B. WOLFFE, M.D.; DONALD FINDLAY, Ph.D.; EDWARD DESSEN, M.D.
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In 1926 E. K. Frey and H. Kraut1 found a substance in the urine which they demonstrated to have vasodilator properties, and which they believed to be a circulation hormone (Kreislaufhormon). In 1929 Frey2 operated on a patient who had a pancreatic cyst and found that the cystic fluid was rich in this particular hormone. They have since studied this product extensively and have come to the following conclusions:
1. The hormone is present in the blood and is excreted in the urine.
2. The hormone is present in the blood mainly in an inactivated form and excreted in the
WOLFFE JB, FINDLAY D, DESSEN E. Treatment of Angina Pectoris With a Tissue Vasodilator Extract-Preliminary Report*†. Ann Intern Med. 1931;5:625–642. doi: https://doi.org/10.7326/0003-4819-5-5-625
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Published: Ann Intern Med. 1931;5(5):625-642.
Cardiology, Coronary Heart Disease.
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