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In addition to applying the biological test described by Dresel to the blood of 24 patients diagnosed clinically as exophthalmic goiter, the urine of 17 of the same group was similarly investigated. In but 13 of these did the mice live to complete the test. The hormone test on the urine was positive in 10, indefinite in 1, and negative in 2. These two patients lacked the lymphoid tissue in the thyroid which is considered indicative of Graves' constitution. It was concluded that when the blood serum or urine from patients with Graves' disease is injected into mice, a substance
A Thyroid Hormone in the Blood and Urine in Graves' Disease.. Ann Intern Med. 1932;5:1556. doi: https://doi.org/10.7326/0003-4819-5-12-1556_2
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Published: Ann Intern Med. 1932;5(12):1556.
Endocrine and Metabolism, Thyroid Disorders.
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