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The senior author and his associates have shown previously that the daily subcutaneous administration of small doses of aliphatic cyanides to young rabbits of either sex, maintained on a diet of alfalfa hay and oats, will produce thyroid hyperplasia within 21 days. Methyl cyanide was found to be most potent in this respect. Rats were given daily subcutaneous injections of varying doses of methyl cyanide in water. After 21 days only very slight thyroid hyperemia was shown. After 28 days there was definite thyroid hypertrophy, but it was obvious that the thyroid of the rat was less reactive than that
Production of Thyroid Hyperplasia in Rats and Mice by Administration of Methyl Cyanide.. Ann Intern Med. ;6:296. doi: 10.7326/0003-4819-6-2-296_2
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Published: Ann Intern Med. 1932;6(2):296.
Endocrine and Metabolism, Thyroid Disorders.
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