W. B. CANNON, M.D.
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We naturally think of ourselves as air inhabiting animals, but even a slight examination would show that we are separated from the air which surrounds us by a layer of dead cells in the outer horny portion of the skin or by a layer of mucus. All that is alive within these lifeless surfaces is bathed in a salty fluid—the "milieu interne", as Claude Bernard called it, or the fluid matrix, as we may designate it. Thus our bodies have not only the external environment which other objects have but our living parts have also an internal environment composed of
CANNON WB. The Functional Organization of the Involuntary Nervous System and Its Humoral Mediators*†. Ann Intern Med. 1933;6:1022–1032. doi: https://doi.org/10.7326/0003-4819-6-8-1022
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Published: Ann Intern Med. 1933;6(8):1022-1032.
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