D. J. STEPHENS, M.D.; J. F. BREDECK, M.D., F.A.C.P.
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In 1904 Albers-Schönberg1 first described the roentgenologic picture of a disease of the skeletal system characterized by transformation of the medullary canal and spongy portions into compact bone. The condition has since been described under various names: Albers-Schönberg disease, osteosclerosis, osteopetrosis, marble bones, Marmorknocken, Marmorskelett, etc. According to Karshner,2 who has recently reviewed the subject, osteosclerosis is hereditary and is due to a primary dyscrasia of the mesenchyme, resulting in abnormal and excessive bone formation. The essential lesion is an increase in thickness of the hard, cortical bone, with condensation and broadening of trabeculae and crowding of the marrow elements,
STEPHENS DJ, BREDECK JF. Aleukemic Myelosis with Osteosclerosis*†. Ann Intern Med. 1933;6:1087–1096. doi: https://doi.org/10.7326/0003-4819-6-8-1087
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Published: Ann Intern Med. 1933;6(8):1087-1096.
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