E. M. WATSON, M.D., F.R.C.P.; W. S. DICK, M.D., M.Sc.
This content is PDF only. Please click on the PDF icon to access.
Recent investigations have pointed to the existence in the blood of a substance which is capable of inhibiting the activity of insulin. Karelitz, Cohen, and Leader,1 as the outcome of an attempt to discover the cause of insulin resistance in a patient with diabetes mellitus, observed that the blood of diabetics, and to a lesser extent that of normal persons, apparently possessed something which was antagonistic in its action to insulin. While this inhibiting property was demonstrated by blood plasma, it was exhibited to a more marked degree by laked red blood cells. Their data were elicited by studying the
WATSON EM, DICK WS. Some Observations Concerning a Possible Insulin-Inhibiting Substance in Urine12. Ann Intern Med. 1933;6:1171–1179. doi: 10.7326/0003-4819-6-9-1171
Download citation file:
Published: Ann Intern Med. 1933;6(9):1171-1179.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use