FRIEDRICH ENGELBACH, M.D.; CHARLES L. BROWN, M.D., F.A.C.P.
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During the last few years the analysis of gastric contents obtained after stimulation by histamine has come into general use.
The work of Bloomfield and Polland1,2 on the acidity of gastric juice following histamine stimulation has shown that the volume and acidity rapidly increase, the maximum being reached in 20 to 30 minutes after injection, after which time the volumes diminish, while the acidity maintains its high level throughout the test of an hour's duration. They found a constancy of response of volume and acid after giving repeated doses of the same amount of histamine to a given individual.
ENGELBACH F, BROWN CL. Variations in the Volume and in the Acid Content of Gastric Secretion of Normal Individuals Following Stimulation by Histamine12. Ann Intern Med. 1933;6:1560–1564. doi: 10.7326/0003-4819-6-12-1560
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Published: Ann Intern Med. 1933;6(12):1560-1564.
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