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The individuality of the various clinical forms of disease depends largely upon the tendency each exhibits to localize differently in the human tissues. The external specificity of symptoms and signs observed by the clinician corresponds to an internal specificity of pathological lesions or of functional disturbances. The factors entering into the determination of the specific localization of disease are to a large extent still obscure though from the earliest times they have been the subject of medical investigation.
In recent years there has been a renewal of activity in the study of the influence of heredity on the occurrence of
CERTAIN FACTORS IN THE LOCALIZATION OF DISEASE. Ann Intern Med. 1933;6:1663–1667. doi: 10.7326/0003-4819-6-12-1663
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Published: Ann Intern Med. 1933;6(12):1663-1667.
DOI: 10.7326/0003-4819-6-12-1663